Superior HPLC columns can be produced only with excellent packing materials and superb packing technique. COSMOSIL columns are well known for their high efficiency and high-resolution separations. Based on spherical, totally porous silica, COSMOSIL columns provide enhanced chemical and mechanical stability as well as very high surface coverage. The selection of the C₁₈?chemistries available enables the chromatographer to tailor separation to special applications. The ultra pure silica based MS-II series with widely extended pH range are developed for improved separation of basic compounds. The C₁₈?AR-II phase provides increased acid resistance. Four unique bonded chemistries are available for Cosmosil specialty columns: Cholester, πNAP, PYE and HILIC. These specialty columns may improve the separation compared with conventional columns. Five highly effective phases for fullerene separation are also available: Buckyprep, Buckyprep-M, PBB, PYE and NPE. COSMOGEL packing materials are non-silica based and provide superior performance in ion exchange columns.