CHIRALPAK ^® ZWIX (+) and CHIRALPAK ^® ZWIX (-) are zwitter ion exchange type chiral columns.

(Such as amino acids, peptides, etc.) which are difficult to be separated on the chiral column of polysaccharide derivatives, and are separated from both the anion exchange group and the cation exchange group.

There is no limitation on the kind of the mobile phase used, and not only methanol and acetonitrile can be used, but also water, tetrahydrofuran and the like can be used as the mobile phase.

The particle size of the filler is 3μm, which greatly improves the separation success rate. 

Daicel expanded its extensive portfolio of immobilized columns to include CHIRALPAK^® ZWIX(+) and CHIRALPAK ZWIX(-), two columns packed with novel zwitterionic chiral stationary phases(CSPs).  The CHIRALPAK ZWIX columns were developed for separation of a great variety of zwitterionic molecules, specifically, for separation of underivatized amino acids, although customers are reporting many successful separations on other difficult-to-separate analytes as well.

ZWIX selectors are zwitterionic molecules that incorporate both anion- and cation-exchange functional groups. These novel ZWIX selectors exhibit exceptional enantioseparation capabilities toward zwitterionic molecules such as amino acids and small peptides.

Chiral Technologies expanded its extensive portfolio of immobilized stationary phases to include two novel zwitterionic chiral stationary phases, CHIRALPAK^® ZWIX(+) and CHIRALPAK ZWIX(-). The CHIRALPAK ZWIX selectors were developed for separation of a great variety of zwitterionic molecules, bearing wide functional diversity, and specifically, for separation of underivatized amino acids. 

The ZWIX selectors are zwitterionic molecules that incorporate both anion- and cation-exchange functional groups. These novel ZWIX selectors exhibit exceptional enantioseparation capabilities toward zwitterionic molecules such as amino acids and peptides. Functionality of the ZWIX selectors, their features and benefits, and their applications for analysis of underivatized amino acids are described in a detailed brochure and a poster presented at HPLC 2012. 

The ZWIX chiral selectors are immobilized on 3-µm silica gel.