CHIRALPAK® OT(+) and OP(+) columns These were the first CSPs invented by Professor Okamoto of Nagoya University (Japan). The chiral selector is a chiral synthetic methacrylate polymer coated onto a 10µm silica support. The best chromatographic results are obtained using 100% Methanol as mobile phase. The polymer used for the CHIRALPAK® OT(+) column is very delicate and is slowly degraded by alcohols. To avoid this phenomenon, we recommend to run the analyses at low temperatures (0 ~ 5°C).