CHIRALCEL® OD-I bulk stationary phase consists of a 20 µm silica support onto which the polymeric chiral selector : cellulose tris (3,5-dimethylphenylcarbamate) has been immobilised. Immobilisation of polysaccharide derivatives on a matrix is an excellent approach to implement universal solvent compatibility. This broadens the range of solvents to be used as mobile phases, thereby introducing new selectivity profiles and beneficial CSP characteristics recommendation.