Great Article Here By Andrew O'Leary

The best way to dispense aliquots of liquid from large supply bottles is to use bottle cap or bottle top dispensers. The requirements of such bottle top dispensers are clear and simple: they must be capable of reproducible dispensing, without wasting any reagent.

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To dispense your liquids with this precision and accuracy, you need to be confident that you liquid handling equipment is properly calibrated. Calibration is an important part of good laboratory practice. No scientist would use a pipette that is not correctly calibrated, and the same level of care should be applied when dispensing liquids using bottle top  dispensers.

In the long run, routine calibration of equipment like bottle top dispensers and pipettes will not only yield higher quality results, but can save your lab money on reagent loss, the need for repeated experiments due to error, and precious man-hours spent in the lab.

Why Do Bottle Top Dispensers Need to be Calibrated?

Just like pipettes, bottle top dispensers need to be calibrated to reliably and repeatedly dispense accurate volumes of liquid. When you know that your equipment is correctly calibrated then you can trust in your experimental results with a greater level of confidence. Bottle top dispensers are usually calibrated using water, for use with liquids of a similar density to water. However, if you are planning on using your bottle top dispenser to dispense liquids with a density or viscosity significantly different to water, you may need to fine tune your instrument volume accordingly.